目的探讨ShyDrager(SDS)综合征的临床特征及其早期诊断。方法回顾性分析7例SDS患者的临床资料。结果7例患者均有直立性低血压、排尿障碍,男性患者均以阳痿为首发症状,其他症状有共济失调、呛咳、喘鸣、帕金森样症状及锥体束征等。给予管通、维生素E、辅酶Q10治疗,症状改善不明显。结论SDS为神经变性性疾病,临床缺乏特异性检查方法,体位性低血压是其重要指标。目前尚缺乏有效治疗手段,预后也差。 Objective To investigate the clinical features and early diagnosis of Shy Drager (SDS) syndrome. Methods The clinical data of 7 patients with SDS were analyzed retrospectively. Results All 7 patients had orthostatic hypotension and voiding dysfunction. Male patients had impotence as their first symptom. Other symptoms included ataxia, choking, wheezing, Parkinson ’s disease and pyramidal tract signs. To Guan Tong, vitamin E, coenzyme Q10 treatment, symptoms were not significantly improved. Conclusion SDS is a neurodegenerative disease, clinical lack of specific examination methods, orthostatic hypotension is an important indicator. Currently there is a lack of effective treatment, the prognosis is poor.