目的探讨Asperger综合征(Asperger syndrome,AS)患儿智力特征,以更好理解和解释其行为表现,为诊断和临床干预提供依据。方法 2002年12月至2009年12月中山大学附属第三医院儿童发育行为专科114例首诊为AS患儿,年龄6岁1个月至14岁3个月,平均(8.31±1.93)岁。均进行韦氏儿童智力量表(C-WISC)测试,分析结果。结果智商分布从轻度智力低下至智力超常,平均言语智商(VIQ)、操作智商(PIQ)和总智商(FIQ)分别为(101.52±18.72)、(88.30±17.40)和(94.90±17.75);AS患儿存在显著(VIQ-PIQ)差距(P<0.01),总趋势是VIQ>PIQ(P<0.01);Kaufman三因子间得分差异有统计学意义(P<0.01);各分测验得分差异有统计学意义(P<0.01),总量表以分类、词汇和知识3个分测验得分较高,以填图、图片排列和编码得分较低;言语分量表以领悟分测验得分最低;操作分量表以木块图和图形拼凑得分较高。结论 AS患儿存在智力发展不平衡,认知优势和劣势并存,在制定教育和训练方案时应利用其言语技能优势,重视非言语技能和社交技能的训练。 Objective To investigate the intelligence characteristics of children with Asperger syndrome (AS) to better understand and explain their behavior and provide the basis for diagnosis and clinical intervention. Methods From December 2002 to December 2009, 114 children with AS in the Third Affiliated Hospital of Sun Yat-sen University were diagnosed as AS, ranging in age from 6 months to 14 years and 3 months (mean, 8.31 ± 1.93 years). Wechsler Children’s Intelligence Scale (C-WISC) test, analysis of the results. Results The IQ distribution ranged from mild to moderate, with VIQ, PIQ and FIQ of (101.52 ± 18.72), (88.30 ± 17.40) and (94.90 ± 17.75), respectively. (P <0.01). The overall trend was VIQ> PIQ (P <0.01). There was significant difference between the Kaufman three-factor scores (P <0.01) (P <0.01). The total scale showed higher scores in terms of classification, vocabulary and knowledge, with lower scores in mapping, pictures arrangement and coding. The speech subscales had the lowest scores in comprehension tests. Scales with wooden block diagram and graphic patchwork higher score. Conclusion Children with AS have unbalanced intelligence development and coexistence of cognitive advantages and disadvantages. They should take advantage of their speech skills in developing their education and training programs, and attach importance to training nonverbal and social skills.