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目的幽门螺杆菌（Helicobacterpylori，Hp）感染与胃癌的发生关系密切．我们剖析胃癌高发区Hp感染状况及其与胃疾病及胃癌的相关性，旨在为Hp感染及胃癌的综合防治提供依据．方法胃癌高发区16村镇胃癌高危人群3033人，经血清胃蛋白酶原检测及X线初筛出1779例，接受了胃粘膜活检精查．其切片作HE及亚甲兰（MB）染色，观察病理组织学改变及Hp感染情况，同时利用PCR检测Hp．结果Hp总检出率为60．8％．其中男高于女；30岁～59岁组最高（62．4％）；山区（64．4％）高于沿海区（56．7％）；胃窦（36．2％）高于胃角（32．6％）及胃体（31．2％）；以上P＜0．01．胃癌Hp检出率为43．8％；各型胃疾病Hp检出率由高至低，前四位依次为胃粘膜糜烂（90．6％）、胃溃疡（87．0％）、中重度浅表性胃炎（79．8％）及萎缩性胃炎（75．3％），上述各组Hp检出率与轻度浅表性胃炎Hp检出率（6．8％）相比，P＜0．01．与未检出Hp的组织学基本正常胃粘膜0％相比，异型增生（80．0％）及肠上皮化生（77．7％）的Hp检出率皆明显升高，P＜0．01．结论庄河居民Hp感染与胃粘膜糜烂、胃溃疡、中重度浅表性胃炎、萎缩性胃炎等呈明显正相关．庄河不仅胃癌高发且Hp感染亦是高流行．文内尚对有关结果只行了初步探讨，呼吁在我国胃癌高发
Objective Helicobacter pylori (Hp) infection is closely related to the occurrence of gastric cancer. We analyze the high incidence of gastric cancer Hp infection and its relationship with gastric diseases and gastric cancer, designed to provide a basis for Hp infection and comprehensive prevention and treatment of gastric cancer. Methods A total of 3033 high-risk gastric cancer patients from 16 villages and high-risk areas of gastric cancer were enrolled in this study. Serum pepsinogen and X-ray screening of 1779 cases were performed, and gastric biopsy was performed. The sections were stained with hematoxylin and eosin (MB), histopathological changes and Hp infection were observed, and Hp was detected by PCR. Results The total detection rate of Hp was 60.8%. (62.4%) in the age group of 30 to 59 years; mountainous area (64.4%) was higher than the coastal area (56.7%); gastric antrum (36.2%) was higher than the stomach angle (32.6%) and gastric body (31.2%); above P <0.01. The detection rate of Hp in gastric cancer was 43.8%. The detection rate of Hp in various types of gastric diseases was high to low. The top four were gastric mucosal erosion (90.6%), gastric ulcer (87.0%), moderate to severe Superficial gastritis (79.8%) and atrophic gastritis (75.3%). The detection rate of Hp in each group was significantly higher than that of mild superficial gastritis (6.8%), P < 0.01. Compared with the 0% of histologically normal gastric mucosa without Hp, the detection rate of Hp in dysplasia (80.0%) and intestinal metaplasia (77.7%) were significantly increased, P <0. 01. Conclusion Hp infection in Zhuanghe residents was positively correlated with gastric mucosal erosions, gastric ulcer, moderate and severe superficial gastritis, atrophic gastritis and so on. Zhuanghe not only high incidence of gastric cancer and Hp infection is also a high prevalence. The article still only on the results of a preliminary study, called for high incidence of gastric cancer in our country