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妇产科感染多为革兰氏阴性杆菌和厌氧菌引起。故应首选对这些病原菌有抗菌活力、组织移行好及副作用少的抗生素。头孢唑肟符合上述条件。为给临床应用提供资料,本文对其向子宫及附件组织移行的情况进行了研究。19例子宫肌瘤或卵巢囊肿患者,术前给予头孢唑肟2g,溶于500ml生理盐水中,静点90分钟。然后在不同时问测定血清、子宫及附件组织中的药物浓度。结果表明,在血清、子宫体、子宫颈、输卵管、卵巢中头孢唑肟的半衰期分别为1.18、1.43、1.24、1.19、1.64小时。投药
Obstetrics and Gynecology infections are mostly caused by Gram-negative bacilli and anaerobic bacteria. It should be the first choice for these pathogens have antibacterial activity, good tissue migration and fewer side effects of antibiotics. Ceftizoxime meets the above conditions. In order to provide information for clinical application, this article studies the migration to the uterus and attachment tissues. 19 cases of uterine fibroids or ovarian cysts in patients given ceftizoxime preoperative 2g, dissolved in 500ml saline, static point 90 minutes. Then at different times to determine the serum, uterine and attachment of the drug concentration in the tissue. The results showed that the half-lives of ceftizoxime in serum, uterus, cervix, oviduct and ovary were 1.18, 1.43, 1.24, 1.19 and 1.64 hours, respectively. Dosing