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目的:研究自噬相关基因beclin 1在唾液腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)中的表达,探讨其与SACC的临床病理特征及患者预后的关系。方法:采用免疫组化法检测79例SACC和20例瘤旁腺体中beclin 1的蛋白表达,分析beclin 1表达与SACC临床病理特征之间的关系。采用SPSS16.0软件包对数据进行统计学分析。结果:Beclin 1在SACC肿瘤组织中的表达显著高于瘤旁腺体(P<0.05)。在SACC肿瘤组织中,Beclin 1表达的高低与组织学分级显著相关(P<0.05),在组织学3级中的表达高于1级和2级。结论:Beclin 1的表达与腺样囊性癌临床病理特征密切相关,对腺样囊性癌诊断和预后评估具有重要参考价值。
OBJECTIVE: To study the expression of autophagy-related gene beclin 1 in salivary adenoid cystic carcinoma (SACC), and to investigate its relationship with the clinicopathological features and prognosis of patients with SACC. Methods: The protein expression of beclin 1 in 79 cases of SACC and 20 cases of parathyroid glands was detected by immunohistochemistry. The relationship between the expression of beclin 1 and the clinicopathological features of SACC was analyzed. SPSS16.0 software package for statistical analysis of the data. Results: The expression of Beclin 1 in SACC tumor tissues was significantly higher than that in the adjacent tumor tissues (P <0.05). In SACC tumor tissues, the expression level of Beclin 1 was significantly correlated with the histological grade (P <0.05), and higher in histological grade 3 than in grades 1 and 2. Conclusion: The expression of Beclin 1 is closely related to the clinicopathological features of adenoid cystic carcinoma, which is of important reference value for the diagnosis and prognosis evaluation of adenoid cystic carcinoma.