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目的:分析17例抗Jo-1抗体综合征病例的临床特点。方法:选取本院2008年1月1日-2015年12月31日收治的Jo-1抗体综合征17例患者的临床资料进行回顾分析。对17例患者的一般资料、临床表现、实验检查及治疗方法进行研究,并对其进行统计学分析。结果:17位患者中包括女11例,男6例,女性与男性的比例为1.8:1,年龄33~69岁,平均(52.21±18.42)岁,病程1个月~8年,平均(25.27±9.93)个月。初治13例,复发病例4例。临床表现包括:肌炎、多关节炎、间质性肺炎、发热、技工手、雷诺现象。间质性肺炎发生率为100%。结论:抗Jo-1抗体综合征患者临床多以多关节炎或肌炎起病,肌炎程度一般较轻。ILD在抗Jo-1抗体综合征中发生率高,为患者主要死因,该病恶性肿瘤伴发率低。
Objective: To analyze the clinical features of 17 cases of anti-Jo-1 antibody syndrome. Methods: The clinical data of 17 patients with Jo-1 antibody syndrome admitted to our hospital from January 1, 2008 to December 31, 2015 were retrospectively analyzed. The general data, clinical manifestations, laboratory tests and treatment methods of 17 patients were studied and statistically analyzed. Results: Among the 17 patients, 11 were women and 6 were males. The ratio of females to males was 1.8: 1, ranging in age from 33 to 69 years (mean 52.21 ± 18.42 years). The duration of disease ranged from 1 month to 8 years (mean, 25.27 ± 9.93) months. Initial treatment in 13 cases, 4 cases of recurrent cases. Clinical manifestations include: myositis, polyarthritis, interstitial pneumonia, fever, mechanic hand, Renault phenomenon. The incidence of interstitial pneumonia was 100%. Conclusions: The patients with anti-Jo-1 antibody syndrome mostly have more arthritis or myositis, and the degree of myositis is generally lighter. The high incidence of ILD in anti-Jo-1 antibody syndrome is the leading cause of death in patients with low rates of malignancy.