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癌症相关性视网膜病变(cancer-associatedretinopathy,CAR)是患视器以外肿瘤的患者发生的一种视网膜变性疾病,与肿瘤的压迫和转移无关。患者多为老年人,视觉症状往往在肿瘤诊断之前出现。典型的临床表现是双眼视力突然下降,在数月内失明,伴有一过性闪光幻觉。眼底正常,或仅有视网膜动脉变细等轻度异常。视野检查有环形暗点,视网膜电图波幅低平或熄灭。病理学改变主要是光感受器严重变性或丧失。皮质类固醇治疗有一定效果。目前认为自身免疫机制在发病中起主要作用,肿瘤释放的激素样物质和EB病毒可能参与致病
Cancer-associatedretinopathy (CAR) is a retinal degenerative disease that occurs in patients with tumors outside of the visual field, independent of tumor oppression and metastasis. Patients are mostly elderly, visual symptoms often appear before tumor diagnosis. A typical clinical manifestation is a sudden drop in binocular vision, blindness within months, with a transient flash illusion. Fundus normal, or only retinal artery thinning and other mild abnormalities. Visual inspection of the ring dark spots, low or flat ECG amplitude flat. Pathological changes are mainly degeneration or loss of photoreceptors. Corticosteroid treatment has a certain effect. Now that the autoimmune mechanism plays a major role in the pathogenesis of tumor-releasing hormone-like substances and Epstein-Barr virus may be involved in pathogenic