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目的 探讨麝香保心分散片对犬急性心肌梗死的保护作用。方法 采用麻醉犬开胸结扎左冠状动脉前降支 (LAD)产生急性心肌梗死 (AMI)模型 ,考察心电图改变、心肌耗氧代谢、心肌梗死面积和心肌酶谱等指标。结果 麝香保心分散片明显缩短QT间期、对心电图ST段升高有明显抑制作用 ,降低心肌耗氧量 ,对心肌耗氧指数有下降趋势 ,对心肌酶谱 3h时的升高有抑制作用 ,缩小心肌梗死面积 ,与对照组比较有统计学意义。结论 麝香保心分散片对犬急性心肌梗死有保护作用
Objective To investigate the protective effect of Shexiangbaoxin dispersible tablets on acute myocardial infarction in dogs. Methods Anaesthetized dogs were used to open the chest and ligation of the left anterior descending coronary artery (LAD) to produce an acute myocardial infarction (AMI) model. Electrocardiogram changes, myocardial oxygen consumption metabolism, myocardial infarct size, and myocardial enzymes were examined. RESULTS: Shexiangbaoxin dispersible tablets significantly shortened the QT interval and significantly inhibited the increase of ST segment in ECG, reduced myocardial oxygen consumption, decreased myocardial oxygen consumption index, and inhibited the increase of myocardial enzyme spectrum at 3 hours. The reduction of myocardial infarct size was statistically significant compared with the control group. Conclusion Shexiang Baoxin Dispersing Tablets can protect dogs against acute myocardial infarction