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[目的]研究母亲孕中期可吸入颗粒物(PM_(10))、二氧化硫(SO_2)、二氧化氮(NO_2)暴露对新生儿出生体重的影响。[方法]依据2008—2012年上海市出生登记系统资料以及上海市环境监测中心在网络上发布的每日PM_(10)、SO_2及NO_2(2007—2012年)等污染物数据,进行回顾性队列研究。共纳入婴儿96.43万,根据母亲孕周和分娩日期计算每位母亲孕中期污染物暴露水平。经比较婴儿及其母亲不同人口学特征间差异,初步发现出生体重的影响因素;用多元回归分析孕中期污染物与出生体重的关系,并且研究在3种污染物互相协同或拮抗的情况下,其对出生体重的影响。[结果]母亲孕中期3种污染物暴露对新生儿出生体重的影响均呈负效应。单因素模型中,孕中期暴露PM_(10)和SO_2的平均质量浓度每增加10μg/m~3,新生儿出生体重分别减少4.4 g和1.1 g。在双污染物模型中,在SO_2或NO_2存在的情况下,PM_(10)对出生体重的影响,比其单独存在时更明显。在三污染物模型中,3种污染物同时存在时,孕中期暴露PM_(10)和SO_2的平均质量浓度每增加10μg/m~3,新生儿出生体重分别减少20.7 g和3.5 g。[结论]母亲孕中期空气污染物暴露与新生儿出生体重相关,空气污染对妊娠结局的影响值得关注。
[Objective] To study the effects of maternal exposure to PM10 (10), SO2 and NO2 on the birth weight of newborns in the second trimester of pregnancy. [Methods] Based on the data of birth registration system in Shanghai from 2008 to 2012 and the daily PM10, SO2 and NO2 (2007-2012) data released by Shanghai Environmental Monitoring Center, a retrospective cohort the study. A total of 964,300 infants were included in this study. The level of second trimester contaminant exposure was calculated on the basis of gestational age of mother and date of childbirth. By comparing the demographic differences between infants and their mothers, the influencing factors of birth weight were initially found. The relationship between the second trimester pollutants and birth weight was analyzed by multivariate regression analysis. When the three pollutants were synergistic or antagonistic, Its impact on birth weight. [Result] The effects of three kinds of pollutants exposure during the third trimester of pregnancy on newborn’s birth weight had a negative effect. In the univariate model, the newborn’s birth weight was reduced by 4.4 g and 1.1 g, respectively, for every 10 μg / m 3 increase in average second-trimester exposure PM 10 and SO 2 concentrations. In the double-pollutant model, the effect of PM_ (10) on birth weight was more obvious than either alone or in the presence of SO_2 or NO_2. In the three pollutants model, with the simultaneous presence of three pollutants, the newborn’s birth weight decreased by 20.7 g and 3.5 g respectively for every 10 μg / m 3 increase in the average mass concentration of PM 10 and SO 2 during the second trimester. [Conclusion] The exposure of maternal mid-second trimester air pollutants is related to the birth weight of infants. The impact of air pollution on pregnancy outcome deserves attention.