细菌生物膜的形成导致临床上细菌对抗生素的耐药性增加,且治疗困难,已受到广泛关注。近年来从基因分子水平对被膜菌的耐药机制进行了研究,业已证实渗透限制、低速生长、休眠菌耐药、细胞凋亡,以及一些相关的基因位点等均与被膜菌耐药密切相关。随之也出现众多治疗被膜菌感染的方法,但目前仍不够完善。 The formation of bacterial biofilm has led to clinical bacterial resistance to antibiotics increased, and the treatment is difficult, has received widespread attention. In recent years, the molecular mechanism of resistance to membrane-bound bacteria has been studied. It has been demonstrated that osmotic restriction, low-speed growth, drug resistance, apoptosis and some related gene loci are all closely related to drug resistance . There are also many ways to treat the infection of the bacteria, but it is still not perfect enough.