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目的调查南阳地区不同年龄腹泻儿童乳糖不耐受的发生情况。方法:随机选取2012年1月-2013年12月间该院收治的感染性腹泻儿童468例为研究组;选取同期在该院行健康体检的非腹泻儿童285例为对照组。采用尿半乳糖氧化酶法测定两组儿童的乳糖不耐受情况并进行统计学分析。结果:研究组儿童乳糖不耐受的阳性率明显高于对照组,差异有统计学意义(P<0.01);研究组儿童中女性乳糖不耐受的阳性率明显高于男性,差异有统计学意义(P<0.01);对照组儿童中不同性别间乳糖不耐受情况无差异(P>0.05)。研究组儿童随着年龄的增长乳糖不耐受阳性率逐渐降低,差异有统计学意义(P<0.01)。研究组儿童中轮状病毒性肠炎引发的乳糖不耐受发生率明显高于其他病因,差异有统计学意义(P<0.01)。结论:小儿腹泻特别是轮状病毒性肠炎易出现继发性乳糖不耐受,应引起临床工作者的重视。
Objective To investigate the incidence of lactose intolerance in diarrhea children of different ages in Nanyang area. Methods: A total of 468 children with infectious diarrhea admitted to our hospital from January 2012 to December 2013 were randomly selected as the study group. 285 healthy non-diarrhea children in the same hospital were selected as the control group. Urinary galactose oxidase method was used to determine lactose intolerance in both groups and statistical analysis was performed. Results: The positive rate of lactose intolerance in study group was significantly higher than that in control group (P <0.01). The positive rate of female lactose intolerance in study group was significantly higher than that of male (P <0.01). There was no difference in lactose intolerance among different sexes in the control group (P> 0.05). The positive rate of lactose intolerance of the study group children gradually decreased with age, the difference was statistically significant (P <0.01). The incidence of lactose intolerance caused by rotavirus enteritis in study group was significantly higher than other causes (P <0.01). Conclusions: Secondary diarrhea, especially rotavirus enteritis, is prone to secondary lactose intolerance and should be taken seriously by clinicians.