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目的:探讨哮喘儿童血清Clara细胞分泌蛋白(CCSP)、白细胞介素-18(IL-18)、嗜酸粒细胞趋化蛋白(Eotaxin)水平与哮喘的关系及其检测意义。方法:采用酶联免疫吸附法(ELISA)检测39例支气管哮喘患儿急性发作期血清CCSP、IL-18、Eotaxin的水平,选取同期健康儿童37例作为对照组。结果:哮喘组患儿血清CCSP浓度为(4.5±0.6)ng/m L,低于对照组的(12.4±2.6)ng/m L;哮喘组患儿血清IL-18浓度为(786.6±69.4)pg/m L,高于对照组的(96.3±11.9)pg/m L;哮喘组患儿血清Eotaxin浓度为(147.0±43.0)ng/m L,高于对照组的(84.0±32.0)ng/m L,两组比较差异均有统计学意义(P均<0.05)。结论:CCSP在哮喘患儿呼吸道炎症损伤、修复、呼吸道重塑过程中可能起保护作用;IL-18、Eotaxin因子参与了气道黏膜损伤的病理过程且与哮喘发作密切相关。
Objective: To investigate the relationship between serum Clara cell secretory protein (CCSP), interleukin-18 (IL-18), and Eotaxin in asthmatic children with asthma and its significance. Methods: Serum levels of CCSP, IL-18 and Eotaxin in 39 children with bronchial asthma were detected by enzyme-linked immunosorbent assay (ELISA). 37 healthy children were selected as control group. Results: Serum CCSP levels in asthmatic children were (4.5 ± 0.6) ng / m L less than those in the control group (12.4 ± 2.6) ng / m L; serum IL-18 levels in children with asthma were (786.6 ± 69.4) (96.3 ± 11.9) pg / m L in the control group. The serum Eotaxin concentration in the asthma group was (147.0 ± 43.0) ng / m L, higher than that in the control group (84.0 ± 32.0) ng / m L, the difference between the two groups was statistically significant (P all <0.05). CONCLUSION: CCSP may play a protective role in airway inflammation injury, repair and airway remodeling in children with asthma. IL-18 and Eotaxin are involved in the pathological process of airway mucosal injury and are closely related to asthma attack.