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Noma和Irisawa[1]首次在兔窦房结细胞上记录到超极化激活的内向电流(hyperpolarization-activated current,Ih),后来证实介导Ih的结构为超极化激活环核苷酸门控的阳离子通道(hyperpolarization-activated cyclic nucleotide-gated channels,HCN通道)。在哺乳动物中,HCN通道家族包括4个成员
Noma and Irisawa [1] first recorded hyperpolarization-activated current (Ih) on rabbit sinoatrial node cells and later confirmed that the structure of Ih mediates hyperpolarization-activated cyclic nucleotide gating Of the hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels). In mammals, the HCN channel family includes four members