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Objective. To study the e ffects of two kinds of Chinese herbal me dicine, Radix angelicae sinensis(RAS)(当归)and Shuanghuanglian(SHL)(双黄连) on chronic Pseudomon as aeruginosa(PA)lung infection in a rat model mimicking cystic fibrosis(C F).Methods.Rats were divided into RAS, SHL and control groups. All ra ts were challenged intratracheally with alginate embedded PA and the treatments with herbal medicine started on the same day of challenge. The drugs were admini stered subcutaneously once a day for ten days and the control group was treated with sterile saline.The rats were sacrif iced two weeks after challenge.Results. Significantl y imp roved lung bacterial clearance(P＜0.05, P＜0 .01) and milder macroscopic lung patholog y (P＜0.005) were found in the two treated groups compared to the control group. In the SHL treated group, the neutrophil p ercent in the peripheral blood leukocyte s(P＜0.05), the anti-PA IgG level in serum (P＜0.05), the incidence of lung abscesse s (P＜0.005) and the incidence of acute lung inflammation(P＜0.05) were significantly l o wer than in the control group. The RAS t reatment reduced fever(P＜0.05), decrease d the incidence of lung abscesses(P＜0.00 5) and lung mast cell number (P＜0.05), a nd lowered anti-PA IgG1 level in serum(P ＜0.05) when compared to the control grou p . The anti-PA bacterial activity test in SHL was weakly positive whereas in RAS it was negative.Conclusion.The treatment w ith both herbal medicines could increase the resistance of the rats against PA l ung infection and they therefore might b e potential promising drugs for stimulat ion of the immune system in CF patients with chronic PA lung infection