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我院自1994年7月—1999年1月收治婴儿晚发性维生素K缺乏致颅内出血18例。现报道如下。 1 临床资料 1.1 一般资料 本组18例中男14例,女4例。年龄<3月15例,～6月2例,～9月1例,最小35 d,最大9月。单纯母乳喂养15例,长期腹泻2例,长期用抗生素1例,单纯母乳喂养同时伴长期腹泻1例。 1.2 临床表现 面色苍白伴抽搐16例,喷射性呕吐5例,脑性尖叫4例,针刺处出血不止4例,烦躁不安6例,肺出血1例,前囟饱满紧张17例,对光反射迟钝呼吸节律不齐3例,四肢肌张力增高16例,便血6例。 1.3 实验室检查 凝血酶原时间(PT)均延长,>正常对照4s 10例,8s 4例,2min 2例,5min 1例。红细胞计数<2.0×10~(12)/L 1例,～3.0×10~(12)/L 15例,～4.0×l0~(12)/L 2例。血红蛋白<30 g/L 1例,～60 g/L 1例,～90 g/L 14例,～110 g/L 2例。血小板计数均正常。
In our hospital from July 1994 to January 1999 admitted to infants with delayed onset of vitamin K deficiency caused intracranial hemorrhage in 18 cases. Report as follows now. 1 Clinical data 1.1 General Information The group of 18 patients, 14 males and 4 females. The age of <15 cases in March, ~ 2 cases in June, ~ 1 in September, the minimum 35 d, the maximum in September. There were 15 cases of breastfeeding, 2 cases of long-term diarrhea, 1 case of long-term antibiotics, 1 case of breast-feeding accompanied by long-term diarrhea. 1.2 Clinical manifestations of pale with convulsions in 16 cases, 5 cases of jet vomiting, 4 cases of cerebral screaming, acupuncture bleeding in more than 4 cases, irritability in 6 cases, 1 case of pulmonary hemorrhage, 17 cases of full bones of the anterior fontanelle, the light Reflex unresponsive breathing rhythm in 3 cases, limb muscle tension increased in 16 cases, 6 cases of hematochezia. 1.3 Laboratory Prothrombin time (PT) were extended,> 10 cases of normal control 4s, 8s in 4 cases, 2min in 2 cases, 5min in 1 case. 1 case of erythrocyte count <2.0 × 10-12 / L, ~ 3.0 × 10-12 / L 15 cases, ~ 4.0 × 10-12 / L 2 cases. 1 case of hemoglobin <30 g / L, 1 case of ~ 60 g / L, 14 cases of ~ 90 g / L and 2 cases of ~ 110 g / L. Platelet count were normal.