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目的在原发性开角型青光眼患者中评价美开朗滴眼液和噻吗心安滴眼液的降眼压作用。方法选择开角型青光眼患者66例90只眼,随机分为美开朗组和噻吗心安组,两组用药均为一日2次。共12周,比较两种滴眼液的降眼压作用及局部和全身副作用。结果两组患者用药后眼压均下降,与用药前相比均有显著性差异(P<0.01)。两组间眼压下降值无显著性差异(P>0.05)。用药12周,美开朗组心率平均降低2.5次,噻吗心安组心率平均降低6.3次,两者相比有显著性差异。结论2%美开朗滴眼液和0.5%噻吗心安滴眼液,两者对开角型青光眼患者具有相同的降眼压作用,但对心率的抑制作用2%美开朗滴眼液明显较小。
Objective To evaluate the antihypertensive effect of Melayan and timolol eye drops in patients with primary open-angle glaucoma. Methods Sixty-nine eyes of 66 patients with open-angle glaucoma were randomly divided into Melecalcile group and timolol group. The two groups were given twice-a-day medication. A total of 12 weeks, compared with two drops of intraocular pressure and local and systemic side effects. Results After treatment, IOP decreased in both groups, which were significantly different from those before treatment (P <0.01). There was no significant difference in IOP values between the two groups (P> 0.05). At 12 weeks of treatment, the heart rate of Meilian group decreased by 2.5 times on average, and the heart rate of timolol group decreased by 6.3 times on average, showing significant difference between the two groups. Conclusions 2% Methylene Blue and 0.5% timolol eye drops, both of which have the same ocular hypotensive effect in open-angle glaucoma patients, but have a less pronounced effect on heart rate with 2% .