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应用酶联免疫吸附法（ＥＬＩＳＡ）检测１０２例正常健康人及１１６例肾脏损害者的尿液视黄醇结合蛋白（ＲＢＰ）。正常健康人尿液ＲＢＰ浓度为０．２４±０．０２ｍｇ／Ｌ，肾脏损害者为４．９６±０．９２ｍｇ／Ｌ，两者比较有显著性差异（Ｐ＜０．０５）。１１６例肾脏疾病患者中，２８例为系统性红斑狼疮（２．０１±３．５０ｍｇ／Ｌ），３０例为肾脏炎症（３．０３±２．８８ｍｇ／Ｌ），２０例为肾病综合征（１．０２±０．８７ｍｇ／Ｌ），２４例为尿毒症（１２．９２±３．５０ｍｇ／Ｌ），其它１４例为糖尿病、甲亢、皮肌炎（０．５９±２．０２ｍｇ／Ｌ），均较正常人有显著性差异（Ｐ＜０．０１或Ｐ＜０．０５）。尿ＲＢＰ是近曲小管疾患的敏感指标，对肾小管疾病有重要诊断价值。
Urinary retinol binding protein (RBP) was detected in 102 healthy controls and 116 kidney lesioned patients by enzyme-linked immunosorbent assay (ELISA). The normal healthy human urine RBP concentration of 0.24 ± 0.02mg / L, kidney damage was 4.96 ± 0.92mg / L, the two were significantly different (P <0.05). Of 116 patients with kidney disease, 28 were systemic lupus erythematosus (2.01 ± 3.50 mg / L), 30 were renal inflammation (3.03 ± 2.88 mg / L) and 20 were nephrotic syndrome 1.02 ± 0.87mg / L), 24 cases of uremia (12.92 ± 3.50mg / L), the other 14 cases of diabetes, hyperthyroidism, dermatomyositis (0.59 ± 2.02mg / L) , There were significant differences compared with normal people (P <0.01 or P <0.05). Urine RBP is a sensitive indicator of proximal tubule disease and has important diagnostic value for renal tubular disease.