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目的分析2008-2013年宾阳县疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)发生特征,评价本县AEFI监测系统运行情况。方法通过疑似预防接种异常反应信息管理系统收集宾阳县2008-2013年报告的AEFI个案数据,运用卡方检验的统计方法对相关指标进行描述性流行病学分析。结果宾阳县2008-2013年共报告AEFI为82例,年报告发生率为1.61/10万剂次~7.59/10万剂次,年平均发生率3.16/10万剂次(82/2597229),其中一般反应22例(占26.83%),异常反应51例(占62.20%),偶合症8例(占9.76%),接种事故1例(占1.22%);偶合死亡4例(占4.88%);男女发生比例为2.15∶1.00,男性发生率显著高于女性;0岁组报告的例数最多,为49例(占59.76%);接种卡介苗后发生的AEFI最多,为43例(占52.44%)。结论宾阳县AEFI监测系统运转良好。AEFI主要发生在小年龄组儿童和国家免疫规划疫苗,接种卡介苗后发生的AEFI是监测的工作重点,要继续加强AEFI监测和处置技术培训,提高AEFI的监测和处置水平。
Objective To analyze the characteristics of AEFI in Binyang County from 2008 to 2013 and evaluate the operation of AEFI monitoring system in this county. Methods The data of AEFI cases reported in Binyang County from 2008 to 2013 were collected through the information system of suspected anaphylaxis vaccination and the descriptive epidemiological analysis was performed using the statistical method of chi-square test. Results A total of 82 AEFI cases were reported in Binyang County from 2008 to 2013, with an annual report rate of 1.61 / 100,000 to 7.59 / 100,000 and an average annual incidence of 3.16 / 100,000 doses (82/2597229) Among them, 22 cases (26.83%) were general reactions, 51 cases (62.20%) were abnormal reactions, 8 cases (8.96%) were incurable cases and 1 case (1.22%) were accidental incidents. ; The incidence of males and females was 2.15:1.00, the incidence of males was significantly higher than that of females; the number of reported cases was the highest in 49 (59.76%) in 0-year-old group; 43 cases (52.44% ). Conclusion Binyang AEFI monitoring system is working well. AEFI mainly occurs in children of small age group and national immunization program vaccines. AEFI occurring after BCG vaccination is the focus of monitoring. Technical training on AEFI monitoring and disposal should be further strengthened to improve the level of AEFI monitoring and treatment.