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转化生长因子β(TGF-β)是一个异质性的细胞因子。在不同的条件,它所产生的生物学效应不同。TGF-β对不同类型肿瘤的浸润和转移可有促进或抑制作用;即使同种类型的肿瘤,因动物种类和肿瘤的分化程度不同,其作用也各异,这其中靶细胞TGF-β受体的无有无及数量的多少对TGF-β效应的发挥起着重要作用。
Transforming growth factor beta (TGF-beta) is a heterogeneous cytokine. In different conditions, it produces different biological effects. TGF-β can promote or inhibit the invasion and metastasis of different types of tumors; even if the tumors of the same type have different effects on animal types and tumors, their effects are also different, among which the target cell TGF-β receptor The presence or absence of numbness and the amount of stimuli play an important role in the TGF-β effect.