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目的探讨健康儿童乙肝疫苗应答随访课题中家长拒绝抽血(随访)的原因,寻找可能的改进措施,为本课题后续的顺利进行及今后的科研项目提供依据。方法以立项课题中连续纳入的新疆乌鲁木齐市709名0~6岁健康儿童家长为研究对象,对未及时随访的家长进行电话或面访,了解其原因;通过故障树分析,由树杈分支的级数确定拒绝随访的主要原因。结果基线调查收回709份问卷,8.7%的儿童家长拒绝抽血,母亲为大专及以上学历的家庭不愿抽血的比例为10.1%,与高中以下学历的家庭不愿抽血的4.6%比较,差异有统计学意义(P<0.05);纳入研究的儿童6个月随访率仅为6.8%,未及时随访率为93.2%;拒绝抽血(及时随访)原因以家长主观因素为主,占72.9%,其中包括对课题的不了解(17.3%),对研究人员的不信任(45.7%),认为研究人员专业素质较低(18.0%)。结论了解受试者的需要,提高研究者业务水平从而增加医患信任并提高全民科研意识才能提高健康人群中科学研究项目的依从性。
Objective To investigate the reasons why parents refuse to take blood (Follow-up) in follow-up of Hepatitis B vaccine response in healthy children and find possible improvement measures to provide a basis for the success of this topic and future scientific research projects. Methods 709 parents of children aged 0 ~ 6 years old in Urumchi, Xinjiang were enrolled in the project. The parents who did not follow-up were interviewed by phone or interview to find out the reasons. By fault tree analysis, The series determines the main reason for refusing follow-up. Results In the baseline survey, 709 questionnaires were withdrawn, 8.7% of the children refused to take the blood, 10.1% did not want to take the blood from their mothers with college education or above, compared with 4.6% of the families who did not want to take the blood at higher education level. The difference was statistically significant (P <0.05). The 6-month follow-up rate of children enrolled in the study was only 6.8%, and the non-prompt follow-up rate was 93.2%. The reasons for refusing to take blood were the parents’ subjective factors, accounting for 72.9% %, Including ignorance of the subject (17.3%), distrust of the researcher (45.7%), and low opinion of the researcher (18.0%). Conclusion It is of great importance to understand the needs of subjects, improve the level of researchers’ business, increase the trust between doctors and patients and raise the awareness of all people in order to improve the compliance of scientific research projects in healthy population.