橙皮素是中药中重要的生物活性化合物,具抗氧化和抗癌作用,但其对结肠癌的作用鲜见报道。观察了不同剂量的橙皮素对1,2-二甲基肼(DMH)诱发的结肠癌模型大鼠异常隐窝病灶(ACF)和结肠黏膜细菌酶活性的影响。雄性Wistar大鼠随机分为6组,每组10只。第1组为对照组,喂饲基础饲料;第2 Hesperetin is an important biologically active compound in traditional Chinese medicine. It has antioxidant and anti-cancer effects, but its effect on colon cancer is rarely reported. The effects of different doses of hesperetin on the activity of abnormal crypt foci (ACF) and colonic bacterial enzymes in colon cancer model rats induced by 1,2-dimethylhydrazine (DMH) were observed. Male Wistar rats were randomly divided into 6 groups, 10 in each group. The first group was the control group and fed the basal diet;