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目的探讨进展期胃肠道肿瘤切除术后腹腔温热灌注化疗的疗效。方法108例进展期胃肠道肿瘤随机分为两组:A组58例为腹腔温热灌注化疗组,将预热至45℃的药液(5-氟脲嘧啶1000mg/m2、顺铂40mg/m2稀释于1500ml林格液中)经术中留置的腹腔化疗泵30min内快速注入腹腔内;B组50例为对照组,行静脉化疗(甲酰四氢叶酸钙200mg静滴,第1~6d;5-氟脲嘧啶500mg/m2静滴,第1~6d;顺铂40mg/m2静滴,第1d)。结果毒副作用A组明显低于B组,3年和5年生存率A组明显高于B组,差异均有统计学意义(分别P<0.05和<0.01)。结论进展期胃肠道肿瘤切除术后腹腔温热灌注化疗既能提高患者的生存率又能降低化疗的毒副作用。
Objective To investigate the effect of intraperitoneal hyperthermic perfusion chemotherapy after advanced gastrointestinal tumor resection. Methods A total of 108 patients with advanced gastrointestinal cancers were randomly divided into two groups: Group A (58 cases) were intraperitoneally hyperthermic perfusion chemotherapy group, which were preheated to 45 ℃ (5-fluorouracil 1000mg / m2, cisplatin 40mg / m2 diluted in 1500ml Ringer’s solution) intraperitoneal intraperitoneal chemotherapy pump placed within 30min rapid intraperitoneal injection; group B 50 cases of control group, intravenous chemotherapy (leucovorin 200mg intravenous infusion, 1 ~ 6d ; 5-fluorouracil 500mg / m2 intravenous drip, 1 ~ 6d; cisplatin 40mg / m2 intravenous infusion, 1d). Results The toxic side effects in group A were significantly lower than those in group B, and the 3-year and 5-year survival rates in group A were significantly higher than those in group B (P <0.05 and <0.01, respectively). Conclusion Intraperitoneal hyperthermic perfusion chemotherapy after advanced gastrointestinal tumor resection can both improve the survival rate of patients and reduce the side effects of chemotherapy.