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肺炎克雷伯菌(KPN)是医院内感染常见致病菌,且发病率和耐药率逐年增高;细菌可移动遗传元件(MGE)可携带耐药基因在同种或不同种菌株间转移、传播,加速KPN对临床抗菌药物的耐药及耐药菌的播散,给治疗带来极大困难。本文简述了KPN携带耐药基因MGE的相关研究进展,探讨KPN对β-内酰胺类、氨基糖苷类、喹诺酮类这三大临床抗菌药物的耐药机制。
Klebsiella pneumoniae (KPN) is a common pathogen of nosocomial infection, and its incidence and drug resistance rate are increasing year by year. MGE can transfer drug-resistant genes between isolates of the same or different strains, Spread and accelerate KPN’s resistance to clinical antibacterials and the spread of drug-resistant bacteria, bringing great difficulties to treatment. This article describes the KPN drug-resistant gene MGE related research progress, to explore KPN β-lactams, aminoglycosides, quinolones the three clinical antimicrobial resistance mechanisms.