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目的探讨分析影响乳腺癌哨兵淋巴结核素显像结果的各种因素。方法选择不同部位Ⅰ~Ⅱa期乳腺恶性肿瘤129例,其中瘤体局部切除手术患者17例,分析注射部位、显像剂、显像时间等不同因素对哨兵淋巴结显像结果的影响。结果 99mTc-DX和99mTc-SC哨兵显像的阳性率差异无统计学意义(P>0.5)。但两者哨兵淋巴结显像时间差异有统计学意义(P<0.005)。行乳腺肿瘤局部切除术的患者哨兵淋巴结显像的阳性率低于未行手术的患者,但差异无统计学意义(P>0.05)。不同的注射部位哨兵淋巴显像的阳性率各不相同,差异有统计学意义(P<0.01)。不同位置的肿瘤哨兵淋巴显像阳性率各不相同,但差异无统计学意义(P>0.25)。不同位置内乳淋巴阳性率各不相同,差异有统计学意义(P<0.005)。结论影响乳腺哨兵淋巴显像的因素较多,不同部位注射哨兵淋巴显像率各不相同,以乳晕区注射最高;99mTc-DX较99mTc-SC早;局部切除术对哨兵淋巴显像率无明显影响;不同部位肿瘤哨兵淋巴显像率各不相同,都表现为腋前区最高,中央区及内侧象限内乳淋巴显像率明显高于外侧象限。
Objective To analyze and analyze various factors affecting the results of sentinel lymph node nuclide imaging in breast cancer. Methods A total of 129 patients with stage Ⅰ ~ Ⅱa breast cancer were selected. Seventeen patients underwent partial resection of the tumor. The effects of injection site, imaging agent and imaging time on the outcome of sentinel lymph node imaging were analyzed. Results The positive rates of 99mTc-DX and 99mTc-SC in sentinel imaging were not significantly different (P> 0.5). However, there was significant difference in time of sentinel lymph node imaging (P <0.005). The positive rate of sentinel lymph node imaging in patients undergoing partial resection of breast tumor was lower than that of those without operation, but the difference was not statistically significant (P> 0.05). The positive rates of sentinel lymphoscintigraphy at different injection sites were different, the difference was statistically significant (P <0.01). The positive rates of sentinel lymphoscintigraphy were different in different locations, but the difference was not statistically significant (P> 0.25). The positive rates of breast lymph nodes in different locations were different, the difference was statistically significant (P <0.005). CONCLUSIONS: There are many factors influencing sentinel lymphoscintigraphy in breast. The rates of sentinel lymphography in different sites are different, and the highest in areola area is injected. 99mTc-DX is earlier than 99mTc-SC. There is no significant difference between the two groups Influence; different parts of the sentinel lymphatic imaging rates vary, are manifested as the highest axillary region, central and medial quadrant within the lymphatic imaging was significantly higher than the lateral quadrant.