论文部分内容阅读
目的探讨尿毒症患者血液透析前后多项血清因子包括肿瘤坏死因子(TNF),白细胞介素-6(IL-6)、C-反应蛋白(CRP)的水平变化,确定血清因子在尿毒症诊断过程中的作用以及透析治疗的效果。方法选取我院收治的尿毒症患者60例为观察组,另选取健康志愿者60例为对照组。对比观察组患者透析前后以及与对照组相比多项血清因子包括TNF、IL-6、CRP的水平变化。结果观察组血液透析治疗前,血清因子水平与对照组相比,明显高于对照组,差异显著,有统计学意义(P<0.05)。观察组透析治疗后,采血检验的血清因子水平和透析前对比发现都有不同程度的下降,且差异明显,有统计学意义(P<0.05)。结论 IL-6、CRP的水平可以作为尿毒症患者的特异性检查,尿毒症患者血液透析治疗效果明显。
Objective To investigate the changes of serum cytokines such as tumor necrosis factor (TNF), interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with uremia before and after hemodialysis and to determine the role of serum factors in the diagnosis of uremia In the role and the effect of dialysis treatment. Methods Sixty uremic patients admitted to our hospital were selected as the observation group and 60 healthy volunteers were selected as the control group. The levels of serum TNF, IL-6 and CRP in the observation group were compared before and after dialysis and compared with the control group. Results Before hemodialysis treatment, serum factor level in observation group was significantly higher than that in control group, with significant difference (P <0.05). After dialysis treatment in observation group, serum levels of blood test and pre-dialysis were found to have varying degrees of decline, and the difference was statistically significant (P <0.05). Conclusion The levels of IL-6 and CRP can be used as a specific test for patients with uremia, and the effect of hemodialysis in uremic patients is obvious.