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一、偏头痛的病理生理学偏头痛是一种不明原因的综合征,包括阵发性头痛及全身症状(特别是胃肠道症状),有时有局限性神经障碍。现代有关偏头痛发病理论主要有两种学说,即血管发病理论和神经发病理论。 1.血管理论 17和18世纪,Willis T等人认为颅内外血管异常对偏头痛发病非常重要。支持这一理论的较新的证据包括血管活性麦角生物碱可消除偏头痛急性发作,血管扩张剂如亚硝酸异戊酯可消除偏头痛先兆发作,而偏头痛先兆发作时局部脑血流是减少的。
First, the pathophysiology of migraine Migraine is an unexplained syndrome, including paroxysmal headache and systemic symptoms (especially gastrointestinal symptoms), and sometimes limited neurological disorders. There are two main theories about the incidence of migraine in modern times, namely, the theory of vascular disease and the theory of neuropathy. 1. Vascular Theory In the 17th and 18th centuries, Willis T et al. (19) considered that extracranial and extravascular abnormalities are important for the onset of migraine. Newer evidence supporting this theory includes the finding that vasoactive alkaloids eliminate acute migraine attacks, vasodilators such as isoamyl nitrite eliminate migraine aura, and local cerebral blood flow is reduced in migraine aura of.