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超氧化物歧化酶类(SODs)与衰老和肿瘤等有密切关系;降钙素基因相关肽(CGRP)分布广,功能复杂;胃动素系-脑-肠肽,其与疾病联系的研究不多。为探讨肿瘤患者血中SODs活力和CGRP、胃动素水平变化及意义,我们采用特异性放射免疫分析法检测原发性肝癌(PHC)患者血浆中CGRP和胃动素含量;采用亚硝酸法检测PHC患者血清中SODs活力。以本院健康工作人员做为对照组。结果显示:Mn-SOD活力为PHC组(24.09±10.23Nu/ml,n=29)明显高于对照组(10.22± 3.02Nu/ml,n=78),P<0.01;CGRP水平为PHC组(3.68±1.39pg/ml,n=18),明显低于对照组(32.99±7.29pg/ml,n=27),P<0.001;胃动素含量为伴肝硬化的PHC组(726.5±33.4pg/ml,、n=18)显著高于对照组(314.6±53.5pg/ml,n=70)和不伴肝硬化的 PHC组(300.7±49.8pg/ml,n=7),P<0.01。经相关分析表明SOD与胃动素
Superoxide dismutases (SODs) are closely related to aging and tumors; calcitonin gene-related peptides (CGRP) are widely distributed and their functions are complex; motilin-brain-gut peptides are not associated with disease research many. To investigate the changes of SODs activity and CGRP and motilin levels in tumor patients, we used specific radioimmunoassay to detect plasma CGRP and motilin levels in patients with primary liver cancer (PHC); SOD activity in serum of PHC patients. The health staff of the hospital served as a control group. The results showed that the Mn-SOD activity was significantly higher in the PHC group (24.09±10.23 Nu/ml, n=29) than in the control group (10.22±3.02 Nu/ml, n=78), P<0.01; the CGRP level was in the PHC group ( 3.68±1.39 pg/ml, n=18), significantly lower than the control group (32.99±7.29 pg/ml, n=27), P<0.001; motilin content in the PHC group with cirrhosis (726.5±33.4pg (/ml,, n=18) were significantly higher than the control group (314.6±53.5 pg/ml, n=70) and PHC group without cirrhosis (300.7±49.8 pg/ml, n=7), P<0.01. Relevant analysis shows that SOD and motilin