动物实验提示,限制蛋白质可延缓慢性肾功能衰竭(CRF)的进程;而已作的临床试验结果却相互矛盾。弄清限制蛋白质摄入究竟能否延缓CRF进程这一问题极其重要,因其不仅关系着临床实践,还对社会和经济有较大的影响。虽然已经有一些临床试验报告,但甚少前瞻性随机化研究,而样本数大的也仅只有一个。为此组织了该项多中心的、前瞻性、随机化试验。共456例成年患者被随机分为低蛋白饮食(每日每公斤体重0.6克)治疗组(266例)和“正常”受控饮食(每日每公斤体重1.0克)对照组(230例)。根据基础血肌酐浓度分层设A(133～221微摩/升)、B(222～442微摩/升)和C(443～619)三个亚组。对每例患者随访两年或至试验终点。试验终点指血肌酐浓度较基础值升 Animal experiments suggest that limiting protein can delay the progression of chronic renal failure (CRF); and the results of the clinical trials have been contradictory. Finding out whether limiting protein intake can delay the progression of CRF is extremely important as it is not only relevant to clinical practice but also has a major impact on society and the economy. Although there have been some clinical trial reports, but very few prospective randomized studies, and only a large sample size. To this end, the multicenter, prospective, randomized trial was organized. A total of 456 adult patients were randomly assigned to a low-protein diet (0.6 grams per kilogram of body weight per day) and a control group (n = 230) of a “normal” controlled diet (1.0 grams per kilogram of body weight per day). According to the basal serum creatinine concentration, A (133 ~ 221 micromol / L), B (222 ~ 442 micromol / L) and C (443 ~ 619) were divided into three subgroups. Each patient was followed up for two years or until the end of the trial. End point of test refers to the serum creatinine concentration than the basic value