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目的观察复方红豆杉胶囊联合放疗治疗中晚期宫颈癌的临床疗效及不良反应发生情况。方法将107例中晚期宫颈癌患者按治疗意愿分为红豆杉组和对照组,红豆杉组在放疗的基础上口服复方红豆杉胶囊3个疗程,对照组予单纯放疗,评价治疗疗效并观察不良反应发生情况。结果两组患者近期有效率和疾病控制率比较差异未见统计学意义;红豆杉组完全缓解率为63%,对照组为47%,红豆杉组明显优于对照组,两组比较差异有统计学意义(P<0.01)。治疗后,红豆杉组Karnofsky评分高于对照组(P<0.01);红豆杉组不良反应发生率明显降低,两组比较差异有统计学意义(P<0.01)。结论复方红豆杉胶囊对中晚期宫颈癌有明显的治疗作用,与放疗联合疗效明显,且能提高中晚期宫颈癌患者的生存质量并降低放疗不良反应的发生率。
Objective To observe the clinical efficacy and adverse reactions of compound yew capsules combined with radiotherapy in the treatment of advanced cervical cancer. Methods 107 patients with advanced cervical cancer were divided into two groups: the yew group and the control group according to the intention to treat. The yew group received oral administration of Radix Fufang capsule three times on the basis of radiotherapy, while the control group received radiotherapy alone to evaluate the curative effect and observed the adverse effects Reaction occurred. Results There was no significant difference in short-term effective rate and disease control rate between the two groups. The rate of complete remission was 63% in the yew group and 47% in the control group, which was significantly better in the yew group than in the control group Significance (P <0.01). After treatment, Karnofsky score of Taxus was higher than that of control (P <0.01). The incidence of adverse reactions in Taxus was significantly lower than that of control (P <0.01). Conclusion The compound yew capsule has a significant therapeutic effect on advanced cervical cancer and has obvious curative effect with radiotherapy. It can also improve the quality of life of patients with advanced cervical cancer and reduce the incidence of adverse reactions of radiotherapy.