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目的 评估锁定钢板固定股骨干骨折时不同螺钉布局对股骨干骨折内固定系统稳定性的影响,为股骨干骨折内固定系统螺钉布局的临床研究提供指导.方法 针对4组螺钉的3个参数化水平进行正交试验方案设计,分别对9组不同螺钉布局的股骨干骨折内固定系统进行生物力学有限元分析,得出各组试验的4项考察指标:接骨板最大等效应力、螺钉最大等效应力、股骨最大等效应力及内固定系统最大轴向位移,并利用权矩阵分析方法进行正交试验数据分析.结果 不同组别螺钉参数对内固定系统稳定性的影响权重不同,4组螺钉参数中对内固定系统稳定性影响的最大权重分别为13.86％、7.57％、7.53％及5.91％.结论 正交试验中螺钉布局的最佳方案为第1组螺纹孔不固定螺钉,第2组螺纹孔固定单皮质螺钉,第3、4组螺纹孔固定双皮质螺钉.“,”Objective To evaluate the effects of locked plates with different screw layouts on stability of the internal fixation system for femoral shaft fracture,so as to provide guidance for clinical study on screw layout of the internal fixation system for femoral shaft fracture.Methods Orthogonal test design method was used with 4 groups of screws at 3 parametric levels.Biomechanical properties of the internal fixation system for femoral shaft fracture under 9 screw layouts were analyzed respectively by the finite element method,and 4 inspection indices,namely,the maximum equivalent stress of the plate,the screw and the femur,and the maximum axial displacement of the internal fixation system were obtained from each group of the experiment,and the orthogonal test weight matrix analysis method was conducted for data analysis.Results The influences of different screw parameters on stability of the internal fixation system varied,and the maximum weights of the 4 sets of screw parameters in stability of the internal fixation system were 13.86％,7.57％,7.53％ and 5.91％,respectively.Conclusions The best scheme for screw layout in orthogonal test is the screw with none-fixed threaded holes in the first group,the single cortical screws with fixed threaded holes in the second group and the double cortical screws with fixed threaded holes in the third and fourth group.