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目的探讨肾病综合征患者血、尿PAI-1浓度的改变及其与疾病的关系。方法分为正常对照组、肾病综合征组,采集激素治疗前后血浆和尿液标本用ELISA法检测PAI-1的含量,速率散射比浊法测定尿清蛋白,常规生化方法检测肾功能。结果肾病综合征组血、尿PAI-1含量升高(P<0.05),血浆和尿液中PAI-1与尿清蛋白浓度无明显相关性(r=0.247,0.234,P>0.05),尿液PAI-1和血肌酐值呈正相关(r=0.37,P<0.05)。激素治疗后比治疗前PAI-1水平降低。结论PAI-1在肾病综合征的发生发展中起重要作用。
Objective To investigate the changes of plasma and urine PAI-1 in patients with nephrotic syndrome and its relationship with the disease. Methods Plasma and urine samples were collected before and after hormone therapy to detect the contents of PAI-1 by ELISA, urine protein by velocity nephelometry and routine renal biochemistry. Results The levels of PAI-1 in blood and urine of nephrotic syndrome group were significantly higher than those of nephrotic syndrome group (P <0.05). There was no significant correlation between PAI-1 and urinary albumin level in plasma and urine (r = 0.247,0.234, P> 0.05) There was a positive correlation between fluid PAI-1 and serum creatinine (r = 0.37, P <0.05). PAI-1 level decreased after hormone therapy than before treatment. Conclusion PAI-1 plays an important role in the occurrence and development of nephrotic syndrome.