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心钠素(cardionatrin)是一种由心房合成,贮存和分泌的具有排钠、利尿作用的活性多肽,亦称心房利钠因子或多肽(atrial natriuretic factor or poly pep-tide,ANF、ANP).自1981年加拿大D-ebold(1)等发现鼠心房肌浸出液具有利尿、排钠、降低血压的生物活性以来,ANP的研究进展迅速.现巳从人类心房组织中分离出ANP,认识到这种肽类激素还参与机体内环境调节,并且还确定ANP的氨基酸序列,同时还进行了人工合成,且试用于临床诊断和治疗.
Cardionatrin, atrial natriuretic factor or polypeptide (ANF), is an active peptide synthesized, stored and secreted by the atrium, which has the function of discharging sodium and diuresis. ANP has been rapidly studied since diarrhea, sodium excretion and hypotensive activity have been found in rat atrial myxoid leachate since 1981 by D-ebold (1) in Canada, etc. It has been found that ANP has been isolated from human atrial tissue Peptide hormones are also involved in the regulation of the environment in the body, and also determine the amino acid sequence of ANP, but also synthetic, and try for clinical diagnosis and treatment.