目的　研究蛋白C(PC)、蛋白S(PS)、活化蛋白C抵抗 (APCR)与急性缺血性脑血管病间的关系。方法　对 80 4例急性脑血管患者及 16 8例非脑血管病患者行PC、PS、APCR检测。结果　在缺血性卒中组PC、PS活性分别为 (115 .8± 12 .5 ) %和 (112 .6± 13.8) % ,明显低于出血性卒中组的 (119.2± 11.3) %和 (112 .1± 16 .5 ) %及对照组的 (12 0 .2± 12 .8) %和 (12 2 .4± 15 .8) % (P <0 .0 1)。进一步比较发现 ,<4 5岁的缺血性卒中组的PC、PS分别为 (5 4 .6 7± 8.9) %和 (40 .4 9± 9.1) % ,明显低于其他各组 ,PS在 4 5岁以上的缺血性卒中组为 (119.2± 15 .6 ) % ,明显低于对照组的 (12 2 .4± 15 .8) % ,(P <0 .0 1) ,其余各组间无显著差异。APCR总发生率 6 .6 % (6 4 / 972 ) ,其中缺血性卒中组为 7.14 % (46 / 6 4 4 ) ,出血性卒中组为 6 .2 5 % (10 /16 0 ) ,两组比较无明显差异 (P >0 .0 5 ) ,4 5岁以下缺血性卒中组APCR的发生率为 4 6 .3% (2 5 / 5 4 ) ,明显高于其他各组。结论　PC、PS活性降低 ,APCR是缺血性脑血管病发生的重要因素 ,特别与 4 5岁以下的缺血性卒中的发生密切相关。 Objective To investigate the relationship between protein C (PC), protein S (PS), activated protein C resistance (APCR) and acute ischemic cerebrovascular disease. Methods 804 acute cerebrovascular patients and 168 non-cerebrovascular patients underwent PC, PS and APCR examinations. Results The PC and PS activities in ischemic stroke group were (115 .8 ± 12. 5)% and (112 .6 ± 13.8)%, respectively, which were significantly lower than those in hemorrhagic stroke group (119.2 ± 11.3) and .1 ± 16.5%) and (12.2 ± 12.8%) and (12.2 ± 4.5%) (P <0.01) in the control group, respectively. Further comparisons revealed that the PC and PS of ischemic stroke group <45 years old were (54.76 ± 8.9)% and (40.49 ± 9.1)%, respectively, which were significantly lower than those in other groups (119.2 ± 15.6%) in the group of ischemic stroke over 5 years old was significantly lower than that of the control group (122.4 ± 15.8%) (P <0.01), while the other groups No significant difference between. The overall incidence of APCR was 6.6% (64/97), with 7.14% (46/644) in the ischemic stroke group and 6.5% (10/1600) in the hemorrhagic stroke group There was no significant difference between the two groups (P> 0.05). The incidence of APCR in ischemic stroke patients under 4 years old was 46.3% (25/54), which was significantly higher than other groups. Conclusions PC, PS activity decreased, APCR is an important factor in the occurrence of ischemic cerebrovascular disease, especially with the occurrence of ischemic stroke in patients under 45 years of age are closely related.