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洛匹那韦作为第二代蛋白酶抑制剂,在艾滋病治疗领域得到广泛应用。然而,该药能被代谢酶CYP3A4快速代谢,在临床应用中,存在较大的个体差异。因此,对洛匹那韦进行药代动力学分析,了解其血药浓度与疗效以及不良反应的关系对优化临床用药具有重要意义。本文全面综述了近年来洛匹那韦浓度分析方法、药代动力学研究进展,为日后洛匹那韦治疗药物监测以及个体化用药研究提供归纳总结材料。
Lopinavir, as a second-generation protease inhibitor, is widely used in the field of AIDS treatment. However, this drug is rapidly metabolized by the metabolic enzyme CYP3A4 and there is a large individual difference in clinical use. Therefore, the pharmacokinetic analysis of lopinavir to understand the relationship between plasma concentration and efficacy and adverse reactions is of great significance for the optimization of clinical medication. This article provides a comprehensive review of the recent advances in the methods and pharmacokinetics of lopinavir for the future monitoring of lopinavir and the study of individualized drug use.