抗心肌缺血药包括抗心绞痛药、抗心肌梗塞药与抗心肌缺血再灌注损伤药,近年进展迅速,已有介绍。本文旨在评价导致这些进展的思路与方法,以期对发展新药有所启发。目前广泛应用的以硝酸酯类和β受体阻滞剂为代表的抗心肌缺血药物的作用原理是节 Anti-ischemic drugs including anti-anginal drugs, anti-myocardial infarction drugs and anti-myocardial ischemia-reperfusion injury drugs, the rapid progress in recent years, has been introduced. This article aims to evaluate the ideas and methods that led to these advances with a view to inspiring new drug development. At present, the principle of action of anti-ischemic drugs, which is widely used as nitrates and beta-blockers, is that