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血管性认知损害(vascular congnitive impairment, VCI)是指脑血管病危险因素、明显或不明显的脑血管病引起的以认知功能障碍为主的一组疾病，表现为慢性或隐袭起病并逐渐发展为痴呆。血清高半胱氨酸(homocysteine, Hcy)水平升高是脑血管病的危险因素之一，高Hcy血症与VCI存在联系，可能通过氧化应激、炎症反应、血管内皮功能障碍、神经细胞毒性等机制参与认知损害的发生和发展过程。分析Hcy参与VCI发生和发展的机制，有望为进一步深入研究VCI的发病机制及防治策略提供依据。“,”Vascular cognitive impairment (VCI) refers to a group of diseases with cognitive dysfunction caused by cerebrovascular disease risk factors and obvious or not obvious cerebrovascular disease, which is characterized by chronic or insidious onset and gradually developing into dementia. Elevated serum homocysteine (Hcy) level is one of the risk factors for cerebrovascular disease. Hyperhomocysteinemia is associated with VCI, which may be involved in the occurrence and development of cognitive impairment through oxidative stress, inflammatory response, vascular endothelial dysfunction, neurotoxicity, and other mechanisms. Analyzing the mechanism of Hcy involved in the occurrence and development of VCI is expected to provide a basis for further research on the pathogenesis and prevention and treatment strategies of VCI.