神经肽Y(neuropeptide Y,NPY)即神经肽酪氨酸,是由36个氨基酸构成的一种活性多肽,属于胰多肽家族,广泛分布于中枢和外周神经系统中,是哺乳动物神经系统内含量最丰富的多肽之一,与焦虑、癫痫间以及某些神经退行性疾病的发生发展存在密切联系[1]。近年来大量研究表明,癫痫间发病的主要因素是中枢神经系统兴奋性与抑制性机制失衡从而导致神经元兴奋性异常增高,而NPY作为一种内源抑制性 Neuropeptide Y (NPY), a neuropeptide tyrosine, is a 36 amino acid active polypeptide belonging to the pancreatic polypeptide family, widely distributed in the central and peripheral nervous system, and is the content of mammalian nervous system One of the most abundant peptides, and anxiety, epilepsy and the occurrence of certain neurodegenerative diseases are closely related [1]. In recent years, a large number of studies have shown that the main factor in the pathogenesis of epilepsy is the imbalance of excitability and inhibitory mechanisms in the central nervous system, which leads to abnormally increased excitability of neurons. NPY, as an endogenous inhibitory