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报道了一种有效地合成5-氟烷基噁唑啉的方法.异氰酸酯与烯丙基胺在二氯甲烷中室温反应得到1-烯丙基-3-芳基脲.1-烯丙基-3-芳基脲与氟烷基碘在乙腈和水的混合液中由连二亚硫酸钠引发在室温下发生自由基加成反应得到氟烷基化的加成产物.加成产物在水或N,N-二甲基甲酰胺(DMF)中加热回流反应得到5-氟烷基噁唑啉.同时我们也可以通过由偶氮二异丁腈(AIBN)引发的1-烯丙基-3-芳基脲的加成环合反应得到5-氟烷基噁唑啉.
A method for the efficient synthesis of 5-fluoroalkyloxazolidines is reported.Isocyanates are reacted with allylamine in dichloromethane at room temperature to give 1-allyl-3-arylureas.1- 3-Arylurea and fluoroalkyl iodide in a mixture of acetonitrile and water by sodium dithionite at room temperature under free radical addition reaction to obtain a fluoroalkylated addition product addition product in water or N, N-dimethylformamide (DMF) to give 5-fluoroalkyloxazoline.In the mean time, we can also obtain the title compound by reaction of 1-allyl-3-aryl The addition reaction of the ureas gives the 5-fluoroalkyl oxazoline.