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目的:探讨中药补肾益精方联合环孢素A、雄激素对再生障碍性贫血患者的治疗效果分析。方法:将73例再生障碍性贫血患者分为两组,对照组采用环孢素A联合雄激素治疗,联合组在对照组治疗基础上采用中药补肾益精方内服,比较两组治疗前后血象指标及血清炎症因子水平变化。结果:联合组总有效率(94.59%)显著高于对照组(77.78%);两组治疗后白细胞、中性粒细胞、血小板、血红蛋白的水平均显著高于治疗前;联合组血象指标改善程度显著优于对照组;两组治疗后血清肿瘤坏死因子-α(TNF-α)、干扰素γ(IFN-γ)、白介素2(IL-2)、白介素6(IL-6)水平均显著降低;联合组血清炎症因子水平降低程度显著优于对照组;联合组不良反应发生率(8.11%)显著低于对照组(27.78%)。结论:中药补肾益精方联合环孢素A、雄激素能显著改善再生障碍性贫血患者血象水平,减轻炎症反应,促进造血功能恢复。
Objective: To investigate the therapeutic effect of Bushen Yijing Decoction combined with cyclosporine A and androgen on patients with aplastic anemia. Methods: A total of 73 patients with aplastic anemia were divided into two groups. The control group was treated with cyclosporin A combined with androgen. The combined group was treated with Bushen Yijing Capsule on the basis of the control group. The blood parameters And serum levels of inflammatory cytokines. Results: The total effective rate (94.59%) in the combination group was significantly higher than that in the control group (77.78%). The levels of leukocyte, neutrophil, platelet and hemoglobin in the two groups were significantly higher than those before treatment Significantly higher than the control group. The levels of TNF-α, IFN-γ, IL-2 and IL-6 in the two groups were significantly decreased after treatment (P <0.05); The combination group serum serumal inflammatory factor level was significantly lower than the control group; combination group adverse reaction rate (8.11%) was significantly lower than the control group (27.78%). Conclusion: Chinese medicine Bushen Yijing Decoction combined with cyclosporin A and androgen can significantly improve the blood level of aplastic anemia patients, reduce the inflammatory reaction and promote the recovery of hematopoietic function.