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研究头孢噻呋钠在成年麻鸭体内的药动学特征及生物利用度,为兽医临床制定合理的给药方案提供科学依据。选取24只健康的成年麻鸭,随机分为3组,以2 mg/kg剂量分别单次肌内注射、静脉注射和内服头孢噻呋钠,采用HPLC法检测血药浓度,计算头孢噻呋的药动力学参数和肌注、内服的生物利用度。结果表明:静脉注射头孢噻呋钠后,血药浓度经时数据符合二室开放模型,主要动力学参数:t1/2α为(0.19±0.22)h,t1/2β为(3.64±0.22)h,Vd为(0.48±0.06)L/kg,CL为(0.07±0.01)L/(kg.h),AUC为(27.09±2.84)μg/(mL.h);肌内注射后,血药浓度经时数据符合二室开放模型,主要动力学参数:t1/2α为(0.38±0.02)h,t1/2β为(4.56±0.29)h,Tmax为(0.49±0.17)h,Cmax为(6.44±0.44)μg/mL,AUC为(26.88±0.49)μg/(mL.h),生物利用度为99.22%;内服后,血药浓度经时数据符合二室开放模型,主要动力学参数:t1/2α为(0.77±0.14)h,t1/2β为(3.81±0.23)h,Tmax为(1.06±0.23)h,Cmax为(3.62±0.20)μg/mL,AUC为(21.47±0.44)μg/(mL.h),生物利用度为79.25%。头孢噻呋钠在成年麻鸭体内吸收迅速,半衰期较长,肌注的生物利用度高,内服吸收良好。
To study the pharmacokinetics and bioavailability of ceftiofur sodium in adult ducks and to provide a scientific basis for veterinary clinic to formulate a reasonable dosing regimen. Twenty-four healthy adult ducks were randomly divided into three groups, intramuscular injection of 2 mg / kg, intramuscular injection of ceftiofur sodium, oral administration of ceftiofur sodium, HPLC method for the determination of ceftiofur Pharmacokinetic parameters and intramuscular injection, oral bioavailability. The results showed that after the injection of ceftiofur sodium intravenously, the data of plasma concentration conformed to the two-compartment open model. The main kinetic parameters were t1 / 2α (0.19 ± 0.22) h and t1 / 2β (3.64 ± 0.22) h, Vd was (0.48 ± 0.06) L / kg, CL was (0.07 ± 0.01) L / (kg.h), AUC was (27.09 ± 2.84) μg / (mL.h) The data were in accordance with the two-compartment open model. The main kinetic parameters were: t1 / 2α was (0.38 ± 0.02) h, t1 / 2β was (4.56 ± 0.29) h, Tmax was (0.49 ± 0.17) h and Cmax was (6.44 ± 0.44) ), the AUC was (26.88 ± 0.49) μg / (mL.h) and the bioavailability was 99.22%. After oral administration, the blood concentration was consistent with two-compartment open model. The main kinetic parameters were t1 / 2α (Cmax) was (3.62 ± 0.20) μg / mL, and the AUC was (21.47 ± 0.44) μg / mL for (0.77 ± 0.14) h and .h), bioavailability was 79.25%. Ceftiofur sodium absorbed rapidly in adult ducks, long half-life, high bioavailability of intramuscular injection, oral absorption well.