In Faranah Province (Guinea), the ratio of supply and demand of c is approximately 1: 2. The production is low and the deficit is covered by maize importation. This study was initiated in order to improve c production by evaluating the effects of increasing doses of mineral fertilizers on the yield and economic profitability of c. The experiment was conducted on a farm in Kamedankoude in a split plot with three replicates. Treatments included two varieties of maize (Perta and Kilissi113) and five doses of chemical fertilizers (D0=unfertilized control, D1=300 kg NPKS+200 kg urea? hm-2; D2=400 kg NPKS+800 kg urea? hm-2; D3=200 kg NPKS+400 kg urea? hm-2 and D4=500 kg NPKS+600 kg urea? hm-2). The results showed that all the agronomic parameters increased with increasing dose of fertilizers, except for the number of ears per plant. The two varieties of c tested produced similar yields. However, the profitability of mineral fertilizers decreased with increased doses and with value/cost ratio of 3. We recommended a mineral fertilizer dose of 300 kg NPKS + 200 kg urea. The high prices of mineral fertilizers were often barriers to intensive maize cultivation, especially for low-income farmers. This study was a contribution to rational fertilization and adapted the socio-economic conditions of the region, with the background knowledge that most farmers in the regions eed low incomes.