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盐酸内咪嗪系三环类抗抑郁药,专用于内因性抑郁症及更年期抑郁症。部颁标准收载,含量测定多用非水滴定法及分光光度法,还有凯氏定氮法、电位滴定法,而电极法尚未见报道。近年来离子选择性电极广泛应用,其中关于膜电极的研制,常用PVC膜或PVF膜,制作费时复杂。本试验利用双液接饱和甘汞电极,外套管腔体微孔陶瓷膜为渗透膜,制成液膜电极,经性能测试结果满意,可用于盐酸内咪嗪及其片剂的含量测定。
Hydrochloride Tricyclic anti-depressant drug, dedicated to endogenous depression and menopausal depression. Ministerial standards contained, determination of multi-use non-aqueous titration and spectrophotometry, as well as Kjeldahl method, potentiometric titration, and the electrode method has not been reported. In recent years, a wide range of ion selective electrodes, of which the development of membrane electrodes, commonly used PVC film or PVF film, making time-consuming and complex. In this experiment, double liquid-permeable calomel electrode and microporous ceramic membrane in the outer cannula were used as the permeable membrane to make the liquid membrane electrode. The results of the performance test were satisfactory and could be used for the determination of the content of the hydrochloride and its tablets.