WO 2007053865 A1利用番石榴苷(guaijaverin)或其盐、或其酯,或番石榴属植物如Psidium cattleianum、P.cattleianum ssp.lucidum、番石榴P.guajava L、P.guineense、草莓番石榴P.littorale、P.molle、P.schiedeanum的提取物作为活性物质制成药物、食品或化妆品,治疗与二肽基肽酶Ⅳ或其类似酶的活性相关的病症或异常,糖代谢障碍,如糖尿病、肥胖症、动脉硬化等。体外实验表明:番石榴苷对二肽基肽酶Ⅳ活性具抑制作用。 WO 2007053865 A1 utilizes guaijaverin or its salt, or its ester, or guava plants such as Psidium cattleianum, P. cattlelia ssp. lucidum, guava P. guajava L, P. guineense, strawberry guava P. The extracts of littorale, P.molle, and P. schiedeanum are used as active substances to prepare medicines, foods, or cosmetics, to treat disorders or abnormalities related to the activity of dipeptidyl peptidase IV or a similar enzyme, and to impair glucose metabolism, such as diabetes, Obesity, arteriosclerosis, etc. In vitro experiments showed that guaiaside inhibited the activity of dipeptidyl peptidase IV.