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Contents1. Overview2. Epidemiology and etiology2.1 Epidemiology2.2 Etiology2.2.1 Genetic factors2.2.2 Smoking2.2.3 Obesity2.2.4 Hypertension and antihypertensive agents2.2.5 Acquired cystic renal disease (ACRD) associated with long-term dialysis of end-st