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目的：观察蛇床子素对小鼠学习记忆的影响并探讨其作用机制。方法：采用避暗实验、跳台实验、Ｙ型水迷路实验观察蛇床子素对小鼠学习记忆的影响，并通过测定脂质过氧化物含量，胆碱酯酶活性分析其作用机制。结果：蛇床子素可显著改善小鼠记忆获得、巩固及方向辨别障碍，但对小鼠记忆再现障碍无明显改善。并能显著延长小鼠断头耐缺氧时间，抑制大鼠肝、脑组织中脂质过氧化物的生成，降低小鼠全血、脑内胆碱酯酶活性。结论：蛇床子素有促进小鼠学习记忆的作用，其机制可能与影响脑内胆碱酯酶活性及延缓细胞老化等因素有关。
Objective: To observe the effect of osthole on learning and memory in mice and to explore its mechanism of action. Methods: The effect of osthole on learning and memory in mice was observed by darkness avoidance test, step-down test, and Y-type water labyrinth test. The mechanism of cholinesterase activity was analyzed by measuring lipid peroxide content. RESULTS: Osthole can significantly improve the memory acquisition, consolidation, and orientation discrimination in mice, but there was no significant improvement in memory impairment of mice. And can significantly prolong the duration of hypoxia tolerance in mice, inhibit the formation of lipid peroxides in rat liver and brain tissue, and reduce the activity of whole blood and intracerebral cholinesterase in mice. CONCLUSION: Osthole has the effect of promoting learning and memory in mice. The mechanism may be related to the factors that affect the activity of cholinesterase in the brain and delay the aging of cells.