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目的探讨血清淀粉酶和脂肪酶联合检测应用于小儿胰腺炎中的临床诊断效果分析。方法 19例小儿胰腺炎患儿作为实验组,19例其他疾病小儿患儿作为对照组。分析不同时间的血清淀粉酶和脂肪酶检测结果、准确度、灵敏度以及特异度等。结果血清淀粉酶和脂肪酶随着患儿病程时间的不断延长而升高,在2~4 h内联合检测血清淀粉酶和脂肪酶阳性率为31.58%;在4~8 h内,脂肪酶的阳性率显著高于血清淀粉酶;在2~4 d后,血清淀粉酶的阳性明显下降,而脂肪酶的阳性率呈较高水平;脂肪酶对小儿胰腺炎患者的特异性显著高于血清淀粉酶,差异有统计学意义(P<0.05);血清淀粉酶和脂肪酶联合检测的准确度、灵敏度以及特异度显著高于单独检测,差异有统计学意义(P<0.05)。结论血清淀粉酶和脂肪酶联合检测应用于小儿胰腺炎中的临床诊断准确度、灵敏度以及特异度较高。
Objective To investigate the clinical diagnosis of pancreatitis in children with amylase and lipase combined detection. Methods Nineteen children with pediatric pancreatitis were included as experimental group and 19 children with other diseases as control group. Analysis of serum amylase and lipase at different times test results, accuracy, sensitivity and specificity and so on. Results Serum amylase and lipase increased with the prolongation of the duration of the disease. The positive rate of serum amylase and lipase was 31.58% within 2 ~ 4 h. In 4 ~ 8 h, The positive rate of serum amylase was significantly higher than that of serum amylase. After 2 to 4 days, the positive rate of serum amylase decreased significantly while the positive rate of lipase was higher. The specificity of lipase to children with pancreatitis was significantly higher than that of serum amylase (P <0.05). The accuracy, sensitivity and specificity of combined detection of serum amylase and lipase were significantly higher than those of single detection (P <0.05). Conclusion Serum amylase and lipase combined detection of pancreatic inflammation in children with clinical diagnosis accuracy, sensitivity and specificity higher.