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他克莫司是一种新的大环内酯类抗生素 ,具有极强的免疫抑制作用 ,但其毒副作用也不可忽视。它的药物动力学受多种因素影响 ,显示广泛的变异性 ,毒副作用在大多数病人中呈现剂量相关性 ,因此对他克莫司进行血药浓度监测很有必要。本文就他克莫司治疗中与药物监测有关的问题如 :样本的选择 ;样品的纯化及预处理 ;血样贮存的稳定性 ;血药浓度监测方法 ;推荐治疗剂量、血药浓度范围、监测频率等进行了综述
Tacrolimus is a new macrolide antibiotic with strong immunosuppressive effects, but its toxic side effects can not be ignored. Its pharmacokinetics are affected by many factors, showing a wide range of variability. Toxicity and side effects are dose-dependent in most patients. Therefore, it is necessary to monitor blood plasma concentration of tacrolimus. In this paper, the problems associated with drug monitoring in the treatment of tacrolimus are as follows: the choice of sample; the purification and pretreatment of samples; the stability of blood storage; the monitoring method of blood concentration; the recommended therapeutic dose, the range of plasma concentration, the monitoring frequency Were reviewed