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目的观察左旋卡尼汀用于胃癌改良消化道重建术后心力衰竭的临床疗效。方法将改良Roux-enY食管(胃)空肠吻合术后心力衰竭患者40例随机分为试验组和对照组,每组20例。试验组给予左旋卡尼汀和常规治疗,对照组仅给予常规治疗,观察2组患者治疗效果及不良反应。结果治疗后试验组LVEDV和LVESV低于对照组,LVEF和心功能改善率显著高于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论左旋卡尼汀用于胃癌改良消化道重建术后心力衰竭疗效显著可有效改善患者心功能,提高治疗效果。值得临床推广应用。
Objective To observe the clinical efficacy of L-carnitine in the treatment of heart failure after modified gastrointestinal reconstruction of gastric cancer. Methods Forty patients with modified heart failure after Roux-enY esophagojejunal anastomosis were randomly divided into experimental group and control group, with 20 cases in each group. The experimental group was given L-carnitine and conventional treatment, the control group was given only conventional treatment, the treatment of two groups were observed and adverse reactions. Results After treatment, the LVEDV and LVESV in the experimental group were lower than those in the control group, and the improvement rate of LVEF and cardiac function in the experimental group was significantly higher than that in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion L-carnitine is effective in improving heart function and improving therapeutic effect in patients with heart failure after modified gastrointestinal reconstruction of gastric cancer. Worthy of clinical application.