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目的 检查annexin Ⅰ在食管癌前病变到食管鳞癌不同病变过程中的表达。方法 按照研究食管癌早期病变的病理学取材方法取材,选择含有不同程度癌前病变的食管鳞癌标本11例,经连续取材制片和免疫组化分析,比较同一病例由食管癌前病变发展到食管鳞癌的全过程中annexin Ⅰ的表达改变。结果 Annexin Ⅰ表达水平在食管正常鳞状上皮中呈强阳性(11/11,100％),低度癌前病变(轻度不典型增生和中度不典型增生)减弱(3/8,37.5％),高度癌前病变(重度不典型增生和原位癌)明显减弱(12/14,85.7/％),食管浸润癌和淋巴结转移癌中阴性或显著减弱(15/15和3/3,100％)。Annex.in Ⅰ在食管低度癌前病变中的改变具有显著意义(P=0.002)。结论 Annexin Ⅰ是食管鳞癌早期侯选标志蛋白,在食管低度癌前病变时表达异常。
Objective To investigate the expression of annexin Ⅰ in esophageal precancerous lesions to different pathological stages of esophageal squamous cell carcinoma. Methods According to the pathological method of early stage of esophageal cancer, 11 cases of esophageal squamous cell carcinoma with different degrees of precancerous lesions were selected and compared with the same cases by esophageal precancerous lesion The expression of annexin Ⅰ in esophageal squamous cell carcinoma changes. Results Annexin Ⅰ expression was strongly positive in the normal esophageal squamous epithelium (11/11,100%). The low grade precancerous lesion (mild dysplasia and moderate dysplasia) was weakened (3/8, 37.5%), Highly precancerous lesions (severe dysplasia and carcinoma in situ) were significantly attenuated (12/14, 85.7%), and negative or significantly decreased (15/15 and 3/3, 100%) in esophageal and lymph node metastases. Annexin Ⅰ in low esophageal precancerous lesions has a significant change (P = 0.002). Conclusion Annexin Ⅰ is an early candidate marker protein in esophageal squamous cell carcinoma, which is abnormally expressed in low esophageal precancerous lesions.