无机物和骨基质移出导致的溶骨性破坏是多发性骨髓瘤的特征。骨骼X 线检查对多发性骨髓瘤的诊断是必要的,但不适用于病人治疗期间的监测。因此需要一种定量估价骨质损伤程度和进展的方法。因为胶原蛋白是骨基质的主要成份,有人认为,胶原蛋白分解产生的尿排泄物(如羟脯氨酸)是估价多发性骨髓瘤病变程度的较好指标。 The osteolytic destruction resulting from the removal of inorganic substances and bone matrix is ​​characteristic of multiple myeloma. X-ray examination of bones is necessary for the diagnosis of multiple myeloma, but it is not suitable for monitoring during patient treatment. Therefore, there is a need for a method of quantitatively assessing the extent and progression of bone damage. Because collagen is the main component of bone matrix, it has been suggested that urinary excretion produced by collagen breakdown (eg, hydroxyproline) is a good indicator of the extent of multiple myeloma lesions.